Headache Is often misdiagnosed as a sinus disease because it is under-appreciated that headache may be accompanied by symptoms that are similar to sinusitis: lacrimation, conjunctival redness, runny nose, pain in the sinus region can all accompany headache/ migraine. Cranial autonomic symptoms occur by activation of the trigeminal-autonomic reflex. Parasympathetic efferents that innervate the lacrimal …